Thionyl Chloride → 3-Chloro-2-(chloromethyl)-4-methoxy-5-methylpyridine hydrochloride

HRID 2093546ノート

反応式

HRID 2093546 の反応式
[Cl:1][C:2]1[C:3]([CH2:11]O)=[N:4][CH:5]=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9].S(Cl)([Cl:15])=O>C(Cl)(Cl)Cl>[ClH:1].[Cl:1][C:2]1[C:3]([CH2:11][Cl:15])=[N:4][CH:5]=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 58201206HCID 58201206、化合物

生成物 1

HCID 666179323-Chloro-2-(chloromethyl)-4-methoxy-5-methylpyridine hydrochloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

The above (3-chloro-4-methoxy-5-methylpyridin-2-yl)methanol (530 mg) was dissolved in 20 ml of chloroform, and thionyl chloride (1.03 ml) was then added dropwise to the solution under cooling on ice. The resulting mixture was stirred at room temperature for 3 hours. Thereafter, the reaction solution was concentrated, and it was then washed with a mixed solvent of ether-hexane, so as to obtain the title compound (410 mg) as a solid.

後処理

  1. temperatureunder cooling on ice
  2. concentrationThereafter, the reaction solution was concentrated
  3. washit was then washed with a mixed solvent of ether-hexane

出典と根拠

ORDレコード
ord-5e5d6105d9ae4cd9a1f7844ae3e41eb7
出典データセット
uspto-grants-2013_05
特許番号
US08445504B2

反応ノート

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