Thionyl Chloride → 4-(Morpholin-3-on-4-yl)-3-nitro-benzoic acid chloride

HRID 2094259

反応式

HRID 2094259 の反応式
[C:1]([CH2:4][O:5][CH2:6][CH2:7][NH:8][C:9]1[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][C:10]=1[N+:18]([O-:20])=[O:19])(O)=[O:2].S(Cl)([Cl:23])=O>ClCCl.CN(C=O)C>[N:8]1([C:9]2[CH:17]=[CH:16][C:12]([C:13]([Cl:23])=[O:14])=[CH:11][C:10]=2[N+:18]([O-:20])=[O:19])[CH2:7][CH2:6][O:5][CH2:4][C:1]1=[O:2]

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 667319084-(2-Carboxymethoxy-ethylamino)-3-nitro-benzoic acid

生成物 1

HCID 860694074-(Morpholin-3-on-4-yl)-3-nitro-benzoic acid chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

290 mg (1.02 mmol) 4-(2-carboxymethoxy-ethylamino)-3-nitro-benzoic acid in 100 ml dichloromethane are combined with 0.186 ml (2.55 mmol) thionyl chloride and 2 drops of DMF and refluxed for one day. After evaporation of the solution i. vac. it is evaporated with toluene and the residue is further reacted without any more purification.

後処理

  1. temperaturerefluxed for one day
  2. customAfter evaporation of the solution i
  3. customit is evaporated with toluene
  4. customthe residue is further reacted without any more purification

出典と根拠

ORDレコード
ord-cc7afd95aa38442e8bcc227179813f27
出典データセット
uspto-grants-2013_05
特許番号
US08445525B2

関連ノート

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