HCID 86642678、化合物 → HCID 67317933、化合物
反応式
[NH:1]1[CH:5]=[CH:4][C:3](/[CH:6]=[CH:7]/[C:8]([O:10][CH2:11][CH2:12][CH2:13][CH3:14])=[O:9])=[CH:2]1>C1COCC1.[Pd]>[NH:1]1[CH:5]=[CH:4][C:3]([CH2:6][CH2:7][C:8]([O:10][CH2:11][CH2:12][CH2:13][CH3:14])=[O:9])=[CH:2]1参加物
4
実験手順
To a solution of (E)-butyl 3-(1H-pyrrol-3-yl)acrylate (2.0 g, 10.4 mmol) in 50 mL of THF was added Pd (10% on activated carbon; 0.50 g). The solution was deoxygenated under vacuum, and H2 was introduced to the reaction flask from a balloon. The process was repeated three times, and the reaction mixture was stirred for 4 h at room temperature. The mixture was filtered through celite, and the filtrate was evaporated under reduced pressure to yield butyl 3-(1H-pyrrol-3-yl)propionate (2.0 g, 99%) as a light-yellow oil. LC-MS (ESI) m/z 196 (M+H+).
後処理
- customThe solution was deoxygenated under vacuum, and H2
- additionwas introduced to the reaction flask from a balloon
- filtrationThe mixture was filtered through celite
- customthe filtrate was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-c4af784d45624ccaa9d5123dc45551dc
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08445684B2
反応ノート
読み込み中…