Tetrahydrofuran → 5-ethyl-2-(4-fluorophenyl)-1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid
反応式
[CH2:1]([C:3]1[N:7]([CH3:8])[N:6]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[C:5](=[O:16])[C:4]=1[C:17]([O:19]CC)=[O:18])[CH3:2].O1CCCC1.[OH-].[Na+]>CO>[CH2:1]([C:3]1[N:7]([CH3:8])[N:6]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[C:5](=[O:16])[C:4]=1[C:17]([OH:19])=[O:18])[CH3:2]参加物
5
実験手順
In the same manner as in Reference Example 65 and using ethyl 5-ethyl-2-(4-fluorophenyl)-1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate (1.9 g, 6.4 mmol), tetrahydrofuran (4 mL), methanol (4 mL) and 4N aqueous sodium hydroxide solution (5 mL) as starting materials, the title compound (1.5 g, 92%) was obtained as a white solid.
出典と根拠
- ORDレコード
- ord-9292f90f7d6f4030ab26c2da46ee89c4
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08445509B2
反応ノート
読み込み中…