Sodium Hydroxide → 2-(2-oxo-1,5-naphthyridin-1(2H)-yl)acetic acid
反応式
[O:1]=[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[N:3]1[CH2:12][C:13]([O:15]C)=[O:14].[OH-].[Na+]>C1COCC1>[O:1]=[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[N:3]1[CH2:12][C:13]([OH:15])=[O:14]参加物
4
反応条件
- 温度
- 70 °C
実験手順
To a solution of methyl 2-(2-oxo-1,5-naphthyridin-1(2H)-yl)acetate (0.205 g, 0.939 mmol) in THF (5 mL) was added sodium hydroxide (0.939 mL of a 3 N aqueous solution, 2.818 mmol) and the reaction mixture was stirred at 70° C. for 0.5 h. The resulting solution was concentrated under vacuum and co-evaporated from toluene to give 2-(2-oxo-1,5-naphthyridin-1(2H)-yl)acetic acid. Retention time (min)=1.033, method [3], MS (ESI) 205.1 (M+H).
後処理
- concentrationThe resulting solution was concentrated under vacuum
出典と根拠
- ORDレコード
- ord-acd788225c094a58a64dd6046a0a5370
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08450363B2
反応ノート
読み込み中…