Nitric Acid → 5-Nitro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
反応式
[N+:1]([O-:4])(O)=[O:2].[O:5]1[CH2:9][CH2:8][C:7]2[CH:10]=[CH:11][CH:12]=[C:13]([C:14]([OH:16])=[O:15])[C:6]1=2>FC(F)(F)C(O)=O>[N+:1]([C:11]1[CH:12]=[C:13]([C:14]([OH:16])=[O:15])[C:6]2[O:5][CH2:9][CH2:8][C:7]=2[CH:10]=1)([O-:4])=[O:2]参加物
4
実験手順
Nitric acid (9 ml) was added to a cooled (ice bath) solution of 2,3-dihydrobenzo[b]furan-7-carboxylic acid (5.1 g, 31 mmol) in trifluoroacetic acid (45 ml). After 4 hours the mixture was quenched into ice-water (150 ml) and the mixture filtered to give 5-nitro-2,3-dihydrobenzo[b]furan-7-carboxylic acid, which was washed with water and used crude (wet) in the next stage.
後処理
- customAfter 4 hours the mixture was quenched into ice-water (150 ml)
- filtrationthe mixture filtered
出典と根拠
- ORDレコード
- ord-c2952578a3d7421c9d062420f5bfdacd
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08450506B2
反応ノート
読み込み中…