Water → 5-Cyano-2,3'-bipyridine-6'-carboxylic acid
反応式
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[N:11][C:12]([C:15]([O:17]C)=[O:16])=[CH:13][CH:14]=2)=[N:7][CH:8]=1)#[N:2].O.[Li+].[OH-]>O1CCCC1>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[N:11][C:12]([C:15]([OH:17])=[O:16])=[CH:13][CH:14]=2)=[N:7][CH:8]=1)#[N:2]参加物
5
実験手順
To a 250 ml flask was added methyl 5-cyano-2,3′-bipyridine-6′-carboxylate (950 mg, 3.57 mmol), water (9.5 ml), tetrahydrofuran (38.4 ml) and LiOH (86 mg, 3.57 mmol). The mixture was stirred for 30 min, diluted with tetrahydrofuran (200 ml) and cooled to 0° C. (ice water batch). After an additional 30 min, the resulting suspension was filtered, washed with THF and dried under reduced pressure to afford the desired product as a light brown powder. LCMS (m/z): 226.1 (M+H).
後処理
- waitAfter an additional 30 min
- filtrationthe resulting suspension was filtered
- washwashed with THF
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-b999a10f9a604241b5d1d6d500c4f2a8
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08450484B2
反応ノート
読み込み中…