Sodium hydride → HCID 86618412、化合物

反応式

[CH3:1][O:2][CH2:3][CH2:4][NH:5][S:6]([CH3:9])(=[O:8])=[O:7].[H-].[Na+].Br[CH2:13][C:14]1[S:22][C:21]2[C:20]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)=[N:19][C:18]([Cl:29])=[N:17][C:16]=2[CH:15]=1>O1CCCC1>[Cl:29][C:18]1[N:19]=[C:20]([N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[C:21]2[S:22][C:14]([CH2:13][N:5]([CH2:4][CH2:3][O:2][CH3:1])[S:6]([CH3:9])(=[O:8])=[O:7])=[CH:15][C:16]=2[N:17]=1

参加物

実験手順

To a solution of N-(2-Methoxy-ethyl)-methanesulfonamide (61 mg) in tetrahydrofuran (1.5 ml) under nitrogen was added sodium hydride, 60% dipersion in mineral oil, (18 mg). The reaction mixture was stirred at room temperature for 30 minutes. 6-Bromomethyl-2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (140 mg) was added. The reaction mixture was stirred at room temperature for 2 hours and then 50° C. for 5 hours. The solvents were removed in vacuo to give a crude product. This was purified by flash chromatography to give N-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-N-(2-methoxy-ethyl)-methanesulfonamide (124 mg).