1,1'-Carbonyldiimidazole → 8-Bromo-7-(4-chlorophenyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

HRID 2101300

反応式

HRID 2101300 の反応式
[Br:1][C:2]1[C:3]([NH:15][NH2:16])=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1.[C:17](N1C=CN=C1)(N1C=CN=C1)=[O:18]>C1COCC1>[Br:1][C:2]1[C:3]2[N:4]([C:17](=[O:18])[NH:16][N:15]=2)[CH:5]=[CH:6][C:7]=1[C:8]1[CH:9]=[CH:10][C:11]([Cl:14])=[CH:12][CH:13]=1

参加物

4

反応物 2

HCID 682631,1'-CarbonyldiimidazoleHCID 577994543-Bromo-4-(4-chlorophenyl)-2-hydrazinylpyridine

生成物 1

HCID 577994388-Bromo-7-(4-chlorophenyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one収率 84.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

Crude 3-bromo-4-(4-chlorophenyl)-2-hydrazinylpyridine (7 g, 23 mmol) was dissolved in dry THF (100 mL), and the resulting solution was cooled to 0° C. To this was added 1,1′carbonyldiimidazole (18 g, 111 mmol). The reaction mixture was stirred at room temperature for 10 h. The solvent was evaporated under vacuum, and water (10 mL) was added, which caused solid desired product to precipitate. This was filtered, washed with water (2×25 mL), and dried to obtain the title compound as a yellow solid (6.3 g), which was used without further purification.

後処理

  1. customThe solvent was evaporated under vacuum, and water (10 mL)
  2. additionwas added
  3. customto precipitate
  4. filtrationThis was filtered
  5. washwashed with water (2×25 mL)
  6. customdried

出典と根拠

ORDレコード
ord-f2374dc14b034ee3ace9ba8e8e5d09e1
出典データセット
uspto-grants-2009_08
特許番号
US07572808B2

関連ノート

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