Triethylsilane → 2-Chloro-4-ethyl-1-fluorobenzene
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=O)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].C([SiH](CC)CC)C>C(O)(C(F)(F)F)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH3:10])[CH:5]=[CH:6][C:7]=1[F:8]参加物
4
実験手順
To a solution of 3′-chloro-4′-fluoroacetophenone (5.2 g, 30.1 mmol) in 30 mL TFA, was added triethylsilane (14.4 mL, 90.4 mmol). The mixture was stirred at rt for 15 h, then concentrated. The crude product was purified by flash chromatography (100% hexanes, 2×) to afford 1.35 g of Intermediate 221.1 as a colorless oil.
後処理
- concentrationconcentrated
- customThe crude product was purified by flash chromatography (100% hexanes, 2×)
出典と根拠
- ORDレコード
- ord-e628bb131f7d41c080af62910a34c143
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07576098B2
反応ノート
読み込み中…