Triethylsilane → 2-Chloro-4-ethyl-1-fluorobenzene

HRID 2105028

反応式

HRID 2105028 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=O)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].C([SiH](CC)CC)C>C(O)(C(F)(F)F)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH3:10])[CH:5]=[CH:6][C:7]=1[F:8]

参加物

4

反応物 2

HCID 12052TriethylsilaneHCID 5204223'-Chloro-4'-fluoroacetophenone

生成物 1

HCID 187118782-Chloro-4-ethyl-1-fluorobenzene収率 28.3%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

To a solution of 3′-chloro-4′-fluoroacetophenone (5.2 g, 30.1 mmol) in 30 mL TFA, was added triethylsilane (14.4 mL, 90.4 mmol). The mixture was stirred at rt for 15 h, then concentrated. The crude product was purified by flash chromatography (100% hexanes, 2×) to afford 1.35 g of Intermediate 221.1 as a colorless oil.

後処理

  1. concentrationconcentrated
  2. customThe crude product was purified by flash chromatography (100% hexanes, 2×)

出典と根拠

ORDレコード
ord-e628bb131f7d41c080af62910a34c143
出典データセット
uspto-grants-2009_08
特許番号
US07576098B2

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