Tetrahydrofuran → 2-p-Fluoroanilinothiazol-4-ylmethanol

HRID 2107274ノート

反応式

HRID 2107274 の反応式
[F:1][C:2]1[CH:18]=[CH:17][C:5]([NH:6][C:7]2[S:8][CH:9]=[C:10]([C:12](OCC)=[O:13])[N:11]=2)=[CH:4][CH:3]=1.[BH4-].[Na+].O1CCCC1>CO>[F:1][C:2]1[CH:18]=[CH:17][C:5]([NH:6][C:7]2[S:8][CH:9]=[C:10]([CH2:12][OH:13])[N:11]=2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 4311764Sodium borohydrideHCID 15053539Ethyl 4-((4-fluorophenyl)amino)-3,5-thiazolecarboxylate

生成物 1

HCID 150535552-p-Fluoroanilinothiazol-4-ylmethanol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The reaction described in Preparation 50 was repeated, but using 12.04 g of ethyl 2-p-fluoroanilinothiazole-4-carboxylate, 6 g of sodium borohydride, 120 ml of anhydrous tetrahydrofuran, and 70 ml of absolute methanol, giving the title compound as colorless prisms.

後処理

  1. customThe reaction described in Preparation 50

出典と根拠

ORDレコード
ord-0f39d68bf59145b49dc6a5d1ee16aba7
出典データセット
uspto-grants-1990_06
特許番号
US04933355

反応ノート

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