Methanol → 2-Ethylaminothiazol-4-ylmethanol

HRID 2107279ノート

反応式

HRID 2107279 の反応式
[CH2:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([C:9](OCC)=[O:10])[N:8]=1)[CH3:2].[BH4-].[Na+].CO>O1CCCC1>[CH2:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([CH2:9][OH:10])[N:8]=1)[CH3:2]

参加物

5

反応物 3

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 150535414-Thiazolecarboxylic acid, 2-(ethylamino)-, ethyl ester

生成物 1

HCID 150535582-Ethylaminothiazol-4-ylmethanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The reaction described in Preparation 17 was repeated but using 10 g of ethyl 2-ethylaminothiazole-4-carboxylate, 3.8 g of sodium borohydride, 70 ml of methanol and 150 ml of tetrahydrofuran, giving the title compound as a yellow oil.

後処理

  1. customThe reaction described in Preparation 17

出典と根拠

ORDレコード
ord-18504b965a984856b05198669e03bf46
出典データセット
uspto-grants-1990_06
特許番号
US04933355

反応ノート

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