Pyridine → HCID 15005407、化合物
反応式
Br[CH:2]([C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1)[C:3](=O)[CH3:4].[C:14]([NH2:17])(=[S:16])[CH3:15].N1C=CC=CC=1>C1(C)C=CC=CC=1>[C:10]([C:9]1[CH:12]=[CH:13][C:6]([C:2]2[S:16][C:14]([CH3:15])=[N:17][C:3]=2[CH3:4])=[CH:7][CH:8]=1)#[N:11]参加物
5
反応条件
- 温度
- 100 °C
実験手順
A solution of 4-(1-bromo-2-oxopropyl)benzonitrile (0.9 g, 3.83 mmol) in toluene (2 ml) was treated with thioacetamide (0.6 g, 8 mmol) followed by pyridine (0.45 ml). The mixture was warmed to 100° C. for 1 hour, then partitioned between ethyl acetate and brine. The organic layer was dried (MgSO4) and evaporated to a yellow oil. Chromatography on silica gel, eluting with 5% ether in dichloromethane, afforded a pale yellow oil which crystallised (0.52 g, 64%), m.p. 108°-110° C.
後処理
- custompartitioned between ethyl acetate and brine
- dry with materialThe organic layer was dried (MgSO4)
- customevaporated to a yellow oil
- washChromatography on silica gel, eluting with 5% ether in dichloromethane
- customafforded a pale yellow oil which
- customcrystallised (0.52 g, 64%), m.p. 108°-110° C.
出典と根拠
- ORDレコード
- ord-872d67d757f94937be4498c43bc822f2
- 出典データセット
- uspto-grants-1990_06
- 特許番号
- US04935430
反応ノート
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