3-Methoxybenzaldehyde → N-[(3-methoxyphenyl)methylidene]hydroxylamine
反応式
Cl.[NH2:2][OH:3].[OH-].[Na+].[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=1)[CH:11]=O>O>[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=1)[CH:11]=[N:2][OH:3]参加物
5
反応条件
- 温度
- 2.5 °C
実験手順
A solution of hydroxylamine hydrochloride (10 g, 0.144 mol) in distilled water (20 ml) was added to 20%(w/v) aqueous sodium hydroxide solution (28 ml). 3-Methoxybenzaldehyde (14 ml, 0.12 mol) was added in one portion and the mixture was stirred for 2 hours at 0-5° C. The mixture was adjusted to pH7 and extracted with dichloromethane. The extracts were combined, dried (MgSO4) and the solvent removed by evaporation to give the title compound (18.7 g, 100%) as a colourless oil. NMR (CDCl3): 3.8 (s, 3H), 6.9 (m, 1H), 7.1 (m, 2H), 7.15 (m, 1H), 8.1 (s, 1H), 8.6 (br s, 1H).
後処理
- extractionextracted with dichloromethane
- dry with materialdried (MgSO4)
- customthe solvent removed by evaporation
出典と根拠
- ORDレコード
- ord-75b8645a954943b08d7770bcfbaa5034
- 出典データセット
- uspto-grants-2009_04
- 特許番号
- US07521453B2
反応ノート
読み込み中…