Chlorosuccinimide → 3-Chloro-1H-indole-5-carboxylic acid methyl ester

HRID 2113468

反応式

HRID 2113468 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[CH:8]2)=[O:4].[Cl:14]N1C(=O)CCC1=O>CO>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[Cl:14])=[O:4]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 2737635methyl 1H-indole-5-carboxylate

生成物 1

HCID 219987283-Chloro-1H-indole-5-carboxylic acid methyl ester収率 62.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 1.4 g (8 mmol) 1H-indole-5-carboxylic acid methyl ester and 1.28 g (9.6 mmol) N-chlorosuccinimid in 40 mL methanol was stirred at room temperature for 16 h. The mixture was evaporated to dryness and taken up in DCM washed with 1N NaHCO3 aq, dried with MgSO4, filtered and evaporated to dryness to yield 1.05 g (62%) of the title compound. MS(m/e): 210.1 (MH+).

後処理

  1. customThe mixture was evaporated to dryness
  2. washwashed with 1N NaHCO3 aq
  3. dry with materialdried with MgSO4
  4. filtrationfiltered
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-3b5c17169e574e9a83ea3a80bfdc003e
出典データセット
uspto-grants-2008_10
特許番号
US07432255B2

関連ノート

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