Sodium Hydroxide → 3-(2,2'-Bisethylcarbamoyl-2-phenylethoxy)propionic acid

HRID 2114184ノート

反応式

HRID 2114184 の反応式
C[O:2][C:3](=[O:25])[CH2:4][CH2:5][O:6][CH2:7][C:8]([C:20](=[O:24])[NH:21][CH2:22][CH3:23])([C:15](=[O:19])[NH:16][CH2:17][CH3:18])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[OH-].[Na+]>C1COCC1.CO>[CH2:17]([NH:16][C:15]([C:8]([C:20](=[O:24])[NH:21][CH2:22][CH3:23])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:7][O:6][CH2:5][CH2:4][C:3]([OH:25])=[O:2])=[O:19])[CH3:18]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 587063943-(2,2'-Bisethylcarbamoyl-2-phenylethoxy)propionic acid methyl ester

生成物 1

HCID 587063833-(2,2'-Bisethylcarbamoyl-2-phenylethoxy)propionic acid収率 95.8%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

3-(2,2′-Bisethylcarbamoyl-2-phenylethoxy)propionic acid methyl ester (125 mg) was dissolved in THF (0.5 mL) and MeOH (0.5 mL), and 1N sodium hydroxide (0.5 mL) was added thereto. The solution was stirred at room temperature for 1 hour and then concentrated. The residue was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was washed with water and concentrated to give 3-(2,2′-bisethylcarbamoyl-2-phenylethoxy)propionic acid (115 mg).

後処理

  1. concentrationconcentrated
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with water
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-3ca82c3ad52940c8bf431d4ebb6d5cac
出典データセット
uspto-grants-2008_10
特許番号
US07432392B2

反応ノート

読み込み中…