Tetrahydrofuran → HCID 10976559、化合物

HRID 2118417ノート

反応式

HRID 2118417 の反応式
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[C:6](=[O:14])[CH2:7][C:8]2=[O:13])([O-])=O.[H][H].[O:17]1CC[CH2:19][CH2:18]1>C(O)C.[Pd]>[C:18]([CH:7]1[C:6](=[O:14])[C:5]2[C:9](=[CH:10][CH:11]=[CH:12][C:4]=2[NH2:1])[C:8]1=[O:13])(=[O:17])[CH3:19]

参加物

6

反応物 3

HCID 8028TetrahydrofuranHCID 27370564-Nitro-1H-indene-1,3(2H)-dioneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 10976559HCID 10976559、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a suspension of 20.0 g of 4-nitro-1,3-indanedione in 100 mL tetrahydrofuran and 20 mL of ethanol, 1.0 g of 10% Pd/C catalyst was added and the mixture hydrogenated at 50 psi until three molar equivalents of hydrogen were taken up. The catalyst was filtered off and solvent was removed from the filtrate under reduced pressure. Recrystallization from ethanol afforded 14.8 g of the title compound, m.p. 126°-128°.

後処理

  1. additionwas added
  2. filtrationThe catalyst was filtered off
  3. customsolvent was removed from the filtrate under reduced pressure
  4. customRecrystallization from ethanol

出典と根拠

ORDレコード
ord-575875c61fad4d039bced8c5d9564ce2
出典データセット
uspto-grants-1987_07
特許番号
US04678499

反応ノート

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