7-Amino-4-vinylisoindolinone → 7-Amino-4-ethylisoindolinone

HRID 21187

反応式

HRID 21187 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH:12]=[CH2:13])=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2.[H][H]>CN(C=O)C.[Pd]>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:12][CH3:13])=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2

参加物

5

反応物 2

HCID 684886597-Amino-4-vinylisoindolinoneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 684909697-Amino-4-ethylisoindolinone収率 102.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 6228Dimethylformamide溶媒

実験手順

7-Amino-4-vinylisoindolinone (50.0 mg, 0.287 mmol) was dissolved in DMF (2.5 mL), and the solution was added with 10% Pd—C (10 mg) followed by stirring at room temperature for 1.8 hours under normal pressure and hydrogen atmosphere. The reaction mixture was filtered using Celite and the solvent of the filtrate was evaporated under reduced pressure to obtain 7-amino-4-ethylisoindolinone (52.0 mg, quantitative).

後処理

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent of the filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-9b574fe409a9418d963834a7bf341de1
出典データセット
uspto-grants-2010_06
特許番号
US07745641B2

関連ノート

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