7-Amino-4-vinylisoindolinone → 7-Amino-4-ethylisoindolinone
反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH:12]=[CH2:13])=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2.[H][H]>CN(C=O)C.[Pd]>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:12][CH3:13])=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2参加物
5
実験手順
7-Amino-4-vinylisoindolinone (50.0 mg, 0.287 mmol) was dissolved in DMF (2.5 mL), and the solution was added with 10% Pd—C (10 mg) followed by stirring at room temperature for 1.8 hours under normal pressure and hydrogen atmosphere. The reaction mixture was filtered using Celite and the solvent of the filtrate was evaporated under reduced pressure to obtain 7-amino-4-ethylisoindolinone (52.0 mg, quantitative).
後処理
- filtrationThe reaction mixture was filtered
- customthe solvent of the filtrate was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-9b574fe409a9418d963834a7bf341de1
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745641B2
反応ノート
読み込み中…