Ethyl bromoacetate → Ethyl 2-(tetramethylcyclopentadienyl)acetate
反応式
Br[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH3:8][C:9]1[CH-:13][C:12]([CH3:14])=[C:11]([CH3:15])[C:10]=1[CH3:16].[Na+]>C1COCC1>[CH3:8][C:9]1[CH:13]([CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4])[C:12]([CH3:14])=[C:11]([CH3:15])[C:10]=1[CH3:16]参加物
4
実験手順
A solution of 3.822 g (22.89 mmol) ethyl bromoacetate in 25 mL THF was cooled to −78° C. and 3.000 g (20.80 g) sodium tetramethylcyclopentadienide in 50 mL THF was slowly added to it. The resulting slurry was allowed to warm to room temperature and was stirred overnight. The solvent was removed, the residue was extracted with pentane and filtered. The pentane was removed to give a mixture of isomers. Yield was 3.733 g (86.3%). Mass spectra m/e 208 (41 percent).
後処理
- customThe solvent was removed
- extractionthe residue was extracted with pentane
- filtrationfiltered
- customThe pentane was removed
- customto give
- additiona mixture of isomers
出典と根拠
- ORDレコード
- ord-36be9dc8732d4c6ab705896d1722a614
- 出典データセット
- uspto-grants-2004_02
- 特許番号
- US06686488B2
反応ノート
読み込み中…