Sodium Carbonate → 4-Amino-2,3-dichlorophenyl thiocyanate

HRID 2120365ノート

反応式

HRID 2120365 の反応式
[Cl:1][C:2]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[S-:10][C:11]#[N:12].[Na+].BrBr.[Br-].[Na+].C(=O)([O-])[O-].[Na+].[Na+]>CO.O>[Cl:1][C:2]1[C:8]([Cl:9])=[C:7]([S:10][C:11]#[N:12])[CH:6]=[CH:5][C:3]=1[NH2:4]

参加物

8

反応物 5

HCID 10340Sodium CarbonateHCID 118442,3-DichloroanilineHCID 24408BromineHCID 253881Sodium BromideHCID 516871Sodium thiocyanate

生成物 1

HCID 146019304-Amino-2,3-dichlorophenyl thiocyanate収率 88%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒2 回HCID 962Water溶媒

実験手順

To a cold (0-5° C.) solution of 2,3-dichloroaniline (2 g) and sodium thiocyanate (3 g) in MeOH (30 ml), was added a solution of bromine (2 g) in MeOH (10 ml) saturated with sodium bromide. The solution was left to stir for 1 hour. The reaction mixture was poured into water (200 ml) and neutralised with sodium carbonate to pH 8. The solid was collected by filtration and dried to yield the title compound as a white solid (2.38 g) 88%. NMR: 6.35 (s, 2H), 6.81 (d, 1H), 7.55 (d, 1H); m/z (EI+): 218.

後処理

  1. waitThe solution was left
  2. filtrationThe solid was collected by filtration
  3. customdried

出典と根拠

ORDレコード
ord-600422e8e40042edadd21a0ca46711ee
出典データセット
uspto-grants-2004_02
特許番号
US06689909B1

反応ノート

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