Hydrochloric Acid → 4-(Isopropoxymethyl)-pyridine

HRID 21373

反応式

HRID 21373 の反応式
[Na].Cl.Cl[CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1.Cl.[CH:12]([OH:15])([CH3:14])[CH3:13]>>[CH:12]([O:15][CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)([CH3:14])[CH3:13]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 745704-(Chloromethyl)pyridinium chlorideHCID 5360545Sodium

生成物 1

HCID 144422044-(Isopropoxymethyl)-pyridine

実験手順

3.4 g of sodium are dissolved in 120 ml of isopropanol and 11 g (0.067 mol) of 4-chloromethylpyridine-hydrochloride are added. The reaction mixture is refluxed for 10 hours under nitrogen, with stirring, then after cooling it is made weakly acidic with dilute hydrochloric acid and concentrated by evaporation under reduced pressure. The residue is made alkaline with 40% potassium carbonate solution and extracted with ether. After drying with anhydrous sodium sulphate the organic phase is concentrated by evaporation. The crude product is then distilled.

後処理

  1. temperatureThe reaction mixture is refluxed for 10 hours under nitrogen
  2. temperatureafter cooling it
  3. concentrationconcentrated by evaporation under reduced pressure
  4. extractionextracted with ether
  5. dry with materialAfter drying with anhydrous sodium sulphate the organic phase
  6. concentrationis concentrated by evaporation
  7. distillationThe crude product is then distilled

出典と根拠

ORDレコード
ord-9964c7de6933407d9c2220728e01fc8c
出典データセット
uspto-grants-1995_06
特許番号
US05422353

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