Resorcinol → 7-Hydroxy-4-phenylcoumarin
反応式
[C:1]1([CH:8]=[CH:7][CH:6]=[C:4]([OH:5])[CH:3]=1)[OH:2].[C:9]([CH2:17][C:18](OCC)=[O:19])(=O)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>OP(O)(O)=O>[OH:2][C:1]1[CH:3]=[C:4]2[C:6]([C:9]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:17][C:18](=[O:19])[O:5]2)=[CH:7][CH:8]=1参加物
4
反応条件
- 温度
- 85 °C
実験手順
A mixture of resorcinol (20 g), ethyl benzoylacetate (23.8 mL) and O-phosphoric acid (130 mL) was heated at 85° C. (care!) for 1 hr. The solution was cooled, poured onto H2O, extracted 3×EtOAc/THF, washed twice with H2O, and then twice with brine. The organic phase was dried and evaporated. Trituration with Et2O followed by filtration afforded the title compound as a solid.
後処理
- temperatureThe solution was cooled
- additionpoured onto H2O
- extractionextracted 3×EtOAc/THF
- washwashed twice with H2O
- customThe organic phase was dried
- customevaporated
- filtrationTrituration with Et2O followed by filtration
出典と根拠
- ORDレコード
- ord-676f55a760bb46bcbae02c9496dfc607
- 出典データセット
- uspto-grants-1995_06
- 特許番号
- US05424320
反応ノート
読み込み中…