Water → 2,3-Dihydro-6-hydroxy-4,7-dimethoxybenzofuran-5-carboxylic acid

HRID 21577ノート

反応式

HRID 21577 の反応式
[OH:1][C:2]1[C:10]([C:11]([OH:13])=[O:12])=[C:9]([O:14][CH3:15])[C:5]2[CH:6]=[CH:7][O:8][C:4]=2[C:3]=1[O:16][CH3:17].O.[OH-].[Na+].[H][H]>C(O)C.[Pd]>[OH:1][C:2]1[C:10]([C:11]([OH:13])=[O:12])=[C:9]([O:14][CH3:15])[C:5]2[CH2:6][CH2:7][O:8][C:4]=2[C:3]=1[O:16][CH3:17]

参加物

7

反応物 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 122114615-Benzofurancarboxylic acid, 6-hydroxy-4,7-dimethoxy-HCID 178418361HCID 178418361、化合物

生成物 1

HCID 199332212,3-Dihydro-6-hydroxy-4,7-dimethoxybenzofuran-5-carboxylic acid収率 73.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

5 g of 6-hydroxy-4,7-dimethoxybenzofuran-5-carboxylic acid in 75 ml of ethanol/25 ml of H2O/0.8 g of NaOH are hydrogenated in the presence of 1 g of Pd/C (10%) under atmospheric pressure and at 50° C. until uptake of hydrogen is complete. The mixture is filtered, the ethanol is removed by distillation, the aqueous phase is acidified, and the solid is filtered off with suction. 3.7 g of product are obtained and reacted further without purification.

後処理

  1. filtrationThe mixture is filtered
  2. customthe ethanol is removed by distillation
  3. filtrationthe solid is filtered off with suction

出典と根拠

ORDレコード
ord-d4e611dc44724a6b8160f1cb54fb0f2f
出典データセット
uspto-grants-1995_06
特許番号
US05424330

反応ノート

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