Chloroform → N-allyl-5-azaisatoic anhydride

HRID 215790ノート

反応式

HRID 215790 の反応式
[C:1]12[C:7](=[CH:8][CH:9]=[N:10][CH:11]=1)[NH:6][C:5](=[O:12])[O:4][C:2]2=[O:3].[CH2:13](Br)[CH:14]=[CH2:15].C(N(CC)CC)C.C(Cl)(Cl)Cl>CN(C=O)C>[CH2:15]([N:6]1[C:5](=[O:12])[O:4][C:2](=[O:3])[C:1]2=[CH:11][N:10]=[CH:9][CH:8]=[C:7]12)[CH:14]=[CH2:13]

参加物

6

反応物 4

HCID 6212ChloroformHCID 7841Allyl bromideHCID 8471TriethylamineHCID 107970962H-Pyrido[4,3-d][1,3]oxazine-2,4(1H)-dione

生成物 1

HCID 86595201N-allyl-5-azaisatoic anhydride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 5-azaisatoic anhydride (1 mmol, Coppola, G. M. Synthesis 1980, 505) and allyl bromide (1.1 mmol) in DMF is added triethylamine (1.2 mmol) dropwise. The reaction mixture is allowed to stir at room temperature for 12 h after which time CHCl3 is added and the organic layer is washed with water, dried (MgSO4) and the solvent is evaporated to give N-allyl-5-azaisatoic anhydride.

後処理

  1. additionis added
  2. washthe organic layer is washed with water
  3. dry with materialdried (MgSO4)
  4. customthe solvent is evaporated

出典と根拠

ORDレコード
ord-6d46e73ce85047f2bab5e918a410ba72
出典データセット
uspto-grants-2012_06
特許番号
US08193185B2

反応ノート

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