Hydrazinecarboxaldehyde → Hydrazinecarbothioamide, N-(2-fluorophenyl)-2-formyl-

HRID 2163474ノート

反応式

HRID 2163474 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]=[C:9]=[S:10].[CH:11]([NH:13][NH2:14])=[O:12]>O1CCCC1>[CH:11]([NH:13][NH:14][C:9]([NH:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[F:1])=[S:10])=[O:12]

参加物

4

反応物 2

HCID 12229HydrazinecarboxaldehydeHCID 975202-Fluorophenyl isothiocyanate

生成物 1

HCID 2390670Hydrazinecarbothioamide, N-(2-fluorophenyl)-2-formyl-

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Fifty grams (0.33 mole) of 2-fluorophenylisothiocyanate and 20 g. (0.33 mole) of formylhydrazine were refluxed for 7 hours in 500 ml. of tetrahydrofuran (THF). The reaction mixture was allowed to cool and the insoluble product was collected by filtration. The crude product was washed with water, filtered and dried. The yield was 10 g. of 1-formyl-4-(2-fluorophenyl)-3-thiosemicarbazide, mp. about 148°-149° C.

後処理

  1. temperatureto cool
  2. filtrationthe insoluble product was collected by filtration
  3. washThe crude product was washed with water
  4. filtrationfiltered
  5. customdried

出典と根拠

ORDレコード
ord-52fae08ff9694b5e85737a2c1d65fc75
出典データセット
uspto-grants-1979_01
特許番号
US04134914

反応ノート

読み込み中…