Pyridine → HCID 23462411、化合物

HRID 2164063ノート

反応式

HRID 2164063 の反応式
[CH3:1][C:2]1[N:3]2[CH:9]=[C:8]([CH2:10][OH:11])[N:7]=[C:4]2[S:5][CH:6]=1.[C:12]([Cl:17])(=[O:16])[CH2:13][CH2:14][CH3:15].N1C=CC=CC=1>C(Cl)(Cl)Cl>[ClH:17].[CH3:1][C:2]1[N:3]2[CH:9]=[C:8]([CH2:10][O:11][C:12](=[O:16])[CH2:13][CH2:14][CH3:15])[N:7]=[C:4]2[S:5][CH:6]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 8855Butyryl chlorideHCID 13060090HCID 13060090、化合物

生成物 1

HCID 23462411HCID 23462411、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

A solution of 5 g of 3-methyl-6-hydroxymethyl-imidazo-(2,1-b)thiazole in 100 ml of dry chloroform is dropped at 35° into a solution of 15 ml of butyroyl chloride and 12 ml of pyridine in 75 ml of dry chloroform. The suspension obtained is stirred for 1 hour at room temperature and then filtered. The filtrate is concentrated by evaporation. The residue obtained is dissolved in abs.ethanol and a stream of dry hydrochloric acid is bubbled into the solution to yield 4.5 g of 3-methyl-6-butyroxymethyl-imidazo-(2,1-b)thiazole hydrochloride; m.p. 126°-128°.

後処理

  1. customThe suspension obtained
  2. filtrationfiltered
  3. concentrationThe filtrate is concentrated by evaporation
  4. customThe residue obtained
  5. dissolutionis dissolved in abs
  6. customethanol and a stream of dry hydrochloric acid is bubbled into the solution

出典と根拠

ORDレコード
ord-bf2b895b5a224b44a606c6fed5d281c3
出典データセット
uspto-grants-1979_01
特許番号
US04137320

反応ノート

読み込み中…