Pyridine → HCID 23462409、化合物

HRID 2164064ノート

反応式

HRID 2164064 の反応式
[CH3:1][C:2]1[N:3]2[CH:9]=[C:8]([CH2:10][OH:11])[N:7]=[C:4]2[S:5][CH:6]=1.[Cl:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](Cl)=[O:18])=[CH:15][CH:14]=1.N1C=CC=CC=1>C(Cl)(Cl)Cl.C(O)(C)C>[ClH:12].[CH3:1][C:2]1[N:3]2[CH:9]=[C:8]([CH2:10][O:11][C:17](=[O:18])[C:16]3[CH:20]=[CH:21][C:13]([Cl:12])=[CH:14][CH:15]=3)[N:7]=[C:4]2[S:5][CH:6]=1

参加物

6

反応物 3

HCID 1049PyridineHCID 85014-Chlorobenzoyl chlorideHCID 13060090HCID 13060090、化合物

生成物 1

HCID 23462409HCID 23462409、化合物

試薬・触媒・溶媒 2

HCID 3776Isopropanol溶媒HCID 6212Chloroform溶媒2 回

実験手順

A solution of 5 g of 3-methyl-6-hydroxymethyl-imidazo-(2,1-b)thiazole in 100 ml of dry chloroform is dropped at room temperature into a solution of 20 ml of p-chlorobenzoyl chloride and 12 ml of pyridine in 75 ml of dry chloroform. The solution is stirred for 30 minutes at room temperature and filtered. The filtrate is concentrated under vacuum; the residue obtained is dissolved in isopropanol and a stream of dry hydrogen chloride is bubbled into the solution to yield 6 g of 3-methyl-6-p-chlorobenzoyloxymethyl-imidazo-(2,1-b)thiazole hydrochloride; m.p. 198°-199°.

後処理

  1. filtrationfiltered
  2. concentrationThe filtrate is concentrated under vacuum
  3. customthe residue obtained
  4. customa stream of dry hydrogen chloride is bubbled into the solution

出典と根拠

ORDレコード
ord-887bc99944de47bda786d4e9797919dd
出典データセット
uspto-grants-1979_01
特許番号
US04137320

反応ノート

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