3-Acetyl-2,5-dihydro-4-hydroxy-5-methyl-1,2-thiazino[5,6-b]indole-1,1-dioxide → HCID 22749974、化合物

HRID 2164089ノート

反応式

HRID 2164089 の反応式
C([C:4]1[NH:5][S:6](=[O:20])(=[O:19])[C:7]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]([CH3:16])[C:8]=2[C:17]=1[OH:18])(=O)C>C(O)CO.C1C=CC=CC=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>[CH3:16][N:9]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=2[C:7]2[S:6](=[O:20])(=[O:19])[NH:5][CH2:4][C:17](=[O:18])[C:8]1=2

参加物

5

反応物 1

HCID 227500043-Acetyl-2,5-dihydro-4-hydroxy-5-methyl-1,2-thiazino[5,6-b]indole-1,1-dioxide

生成物 1

HCID 22749974HCID 22749974、化合物

試薬・触媒・溶媒 3

HCID 6101p-Toluenesulfonic acid触媒HCID 174Ethylene Glycol溶媒HCID 241Benzene溶媒

実験手順

The acetyl derivates of the formula XII are treated in the presence of an acid and under anhydrous conditions with ethyleneglycol and form the ketals of the formula ##STR13## wherein R2 and Y have the meanings defined above. For example, 3-acetyl-2,5-dihydro-4-hydroxy-5-methyl-1,2-thiazino[5,6-b]indole-1,1-dioxide is refluxed with ethyleneglycol in benzene as a solvent and in the presence of p-toluenesulfonic acid as a catalyst for 5 days, which yields the ethylene ketal of 2,5-dihydro-5-methyl-1,2-thiazino[5,6-b]indole-4(3H)-one-1,1-dioxide.

出典と根拠

ORDレコード
ord-6cb6a8a8061a455b922beb312ed36c06
出典データセット
uspto-grants-1979_01
特許番号
US04137313

反応ノート

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