7-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid → 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(3-(methoxymethyl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid

HRID 2165663

反応式

HRID 2165663 の反応式
Cl[C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:22])[C:7]([C:19]([OH:21])=[O:20])=[CH:8][N:9]2[C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=[CH:4][C:3]=1[F:23].[CH3:24][O:25][CH2:26][CH:27]1[CH2:32][NH:31][CH2:30][CH2:29][NH:28]1>N1C=CC=CC=1>[F:23][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:2]=1[N:31]1[CH2:30][CH2:29][NH:28][CH:27]([CH2:26][O:25][CH3:24])[CH2:32]1)[N:9]([C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1)[CH:8]=[C:7]([C:19]([OH:21])=[O:20])[C:6]2=[O:22]

参加物

4

反応物 2

HCID 573387-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acidHCID 142302642-(Methoxymethyl)piperazine

生成物 1

HCID 148394066-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(3-(methoxymethyl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A 906 mg portion of 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 1.4 g of 2-(methoxymethyl)piperazine were added to 10 ml of pyridine and reacted as described in Example 81, giving 187 mg of the desired product, mp 216°-218° C.

後処理

  1. customreacted

出典と根拠

ORDレコード
ord-8125365767bf4ef0b61cfafca36f90ea
出典データセット
uspto-grants-1990_07
特許番号
US04940710

関連ノート

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