Thionyl Chloride → 3-(Chloromethyl)-8-methyl-2-o-tolylquinoline

HRID 216743ノート

反応式

HRID 216743 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH3:18])[C:8]([CH2:19]O)=[CH:7]2.O=S(Cl)[Cl:23]>C(Cl)(Cl)Cl>[Cl:23][CH2:19][C:8]1[C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])=[N:10][C:11]2[C:6]([CH:7]=1)=[CH:5][CH:4]=[CH:3][C:2]=2[CH3:1]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 57707986(8-Methyl-2-o-tolylquinolin-3-yl)methanol

生成物 1

HCID 575561733-(Chloromethyl)-8-methyl-2-o-tolylquinoline

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Prepared according to Procedure C using (8-methyl-2-o-tolylquinolin-3-yl)-methanol (670 mg, 2.5 mmol) and SOCl2 (0.91 mL, 5 eq) in CHCl3 (10 mL). After isolation, the resultant oil was carried on crude without purification for the next step.

後処理

  1. customPrepared
  2. customAfter isolation, the resultant oil was carried on crude without purification for the next step

出典と根拠

ORDレコード
ord-d6276ba642af47418dcbba960a738f46
出典データセット
uspto-grants-2012_06
特許番号
US08193199B2

反応ノート

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