Bromine → HCID 90185062、化合物

HRID 2167697ノート

反応式

HRID 2167697 の反応式
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:13])[C:10](=[O:12])[CH3:11])=[CH:5][CH:4]=1.[Br:16]Br.S([O-])([O-])(=O)=S.[Na+].[Na+]>C(Cl)(Cl)Cl>[Br:16][CH2:11][C:10](=[O:12])[C:9]([C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:14])([F:15])[F:1])=[CH:8][CH:7]=1)=[O:13]

参加物

5

反応物 3

HCID 24408BromineHCID 24477Sodium ThiosulfateHCID 27776811-[4-(trifluoromethyl)phenyl]propane-1,2-dione

生成物 1

HCID 90185062HCID 90185062、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

反応条件

温度
70 °C

実験手順

To a chloroform (6.0 mL) solution of 1-[4-(trifluoromethyl)phenyl]propane-1,2-dione (0.65 g), bromine (0.62 mL) was added, and the resultant was stirred at 70° C. for 6 hours. After standing to cool to room temperature, a 10% aqueous sodium thiosulfate solution was added thereto, followed by extraction with chloroform. An organic layer was separated using a phase separator, and the solvent was distilled off under reduced pressure to obtain the title compound (1.1 g) as a yellow oil.

後処理

  1. temperatureto cool to room temperature
  2. extractionfollowed by extraction with chloroform
  3. customAn organic layer was separated
  4. distillationthe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-ddd1b302b77b4f358ebda7331f22eccf
出典データセット
uspto-grants-2015_06
特許番号
US09045466B2

反応ノート

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