Hydrochloric Acid → 3-(4-Benzyloxy-phenyl)-1,1,1-trifluoro-propan-2-one

HRID 2168617

反応式

HRID 2168617 の反応式
CO[C:3](=[O:19])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][CH:6]=1.C[Si](C)(C)[C:22]([F:25])([F:24])[F:23].[F-].[Cs+].Cl>C1COCC1>[CH2:12]([O:11][C:8]1[CH:7]=[CH:6][C:5]([CH2:4][C:3](=[O:19])[C:22]([F:25])([F:24])[F:23])=[CH:10][CH:9]=1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 25953Cesium fluorideHCID 552549(Trifluoromethyl)trimethylsilaneHCID 2756645Methyl 2-(4-benzyloxyphenyl)acetate

生成物 1

HCID 673872073-(4-Benzyloxy-phenyl)-1,1,1-trifluoro-propan-2-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of (4-benzyloxy-phenyl)-acetic acid methyl ester (11.7 mmol, 3.0 g), trimethyl-trifluoromethyl-silane and cesium fluoride in THF may be stirred at room temperature for 2 h. Hydrochloride may be added upon consumption of ester as indicated by TLC. The mixture may be stirred further at room temperature until the intermediate disappears as indicated by TLC to provide 3-(4-benzyloxy-phenyl)-1,1,1-trifluoro-propan-2-one.

後処理

  1. stirringThe mixture may be stirred further at room temperature until the intermediate

出典と根拠

ORDレコード
ord-635bf373a0984232bca548a6e1588bee
出典データセット
uspto-grants-2015_06
特許番号
US09045461B2

関連ノート

読み込み中…