Azobisisobutyronitrile → HCID 86674584、化合物

HRID 2170647ノート

反応式

HRID 2170647 の反応式
[Cl:1][C:2]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:3]=1[O:4][C@@H:5]([CH3:10])[C:6]([O:8][CH3:9])=[O:7].C1C(=O)N([Br:23])C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C>C(Cl)(Cl)(Cl)Cl>[Br:23][CH2:15][C:12]1[CH:13]=[CH:14][C:2]([Cl:1])=[C:3]([CH:11]=1)[O:4][C@@H:5]([CH3:10])[C:6]([O:8][CH3:9])=[O:7]

参加物

5

反応物 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 40647465HCID 40647465、化合物

生成物 1

HCID 86674584HCID 86674584、化合物

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

To (S)-methyl 2-(2-chloro-5-methylphenoxy)propanoate (2.4 g, 10.5 mmol) in CCl4 (20 mL) was added NBS (1.92 g, 11.55 mmol) and AIBN (0.35 g, 2.1 mmol). The mixture was refluxed overnight. The reaction mixture was cooled and the solvent was removed to obtain the crude. The crude was purified by flash chromatography (AcOEt/Hexane 0˜30%) to obtain the title compound.

後処理

  1. temperatureThe mixture was refluxed overnight
  2. temperatureThe reaction mixture was cooled
  3. customthe solvent was removed
  4. customto obtain the crude
  5. customThe crude was purified by flash chromatography (AcOEt/Hexane 0˜30%)

出典と根拠

ORDレコード
ord-238bd778d95249b58c745be1cd64de74
出典データセット
uspto-grants-2015_06
特許番号
US09051265B2

反応ノート

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