Hydrochloric Acid → HCID 71075520、化合物

HRID 2170709ノート

反応式

HRID 2170709 の反応式
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([C@@H:11]([NH:13][C:14]([C:16]2[CH:17]=[C:18]3[C:22](=[CH:23][CH:24]=2)[N:21]([CH2:25][C:26]2[CH:27]=[C:28]([CH:36]=[CH:37][CH:38]=2)[O:29][C@@H:30]([CH3:35])[C:31]([O:33]C)=[O:32])[C:20]([CH3:39])=[C:19]3[CH3:40])=[O:15])[CH3:12])[CH:8]=[CH:9][CH:10]=1)([CH3:3])[CH3:2].[Li+].[OH-].Cl>C1COCC1>[CH:1]([O:4][C:5]1[CH:6]=[C:7]([C@@H:11]([NH:13][C:14]([C:16]2[CH:17]=[C:18]3[C:22](=[CH:23][CH:24]=2)[N:21]([CH2:25][C:26]2[CH:27]=[C:28]([CH:36]=[CH:37][CH:38]=2)[O:29][C@@H:30]([CH3:35])[C:31]([OH:33])=[O:32])[C:20]([CH3:39])=[C:19]3[CH3:40])=[O:15])[CH3:12])[CH:8]=[CH:9][CH:10]=1)([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 71075489HCID 71075489、化合物

生成物 1

HCID 71075520HCID 71075520、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of (S)-methyl 2-(3-((5(((S)-1-(3-isopropoxyphenyl)ethyl) carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenoxy)propanoate (70 mg, 0.13 mmol, 1 equiv) in THF (2 mL) was added a 1 N LiOH aqueous solution of (1 mL). The reaction mixture was stirred 6 h at room temperature, then acidified with a 0.5 N HCl aqueous solution. The mixture was filtered and the precipate was dissolved in methanol and concentrated to obtain the crude product which was purified by prep. HPLC (MeOH/Acetonitrile/water 0.1% TFA) to obtain the title compound.

後処理

  1. filtrationThe mixture was filtered
  2. dissolutionthe precipate was dissolved in methanol
  3. concentrationconcentrated
  4. customto obtain the crude product which
  5. customwas purified by prep

出典と根拠

ORDレコード
ord-b573e63655d04466ad0e409b19641a9d
出典データセット
uspto-grants-2015_06
特許番号
US09051265B2

反応ノート

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