Water → 2-Methyl-2-phenylpropan-1-amine

HRID 2172718ノート

反応式

HRID 2172718 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([CH3:11])[C:9]#[N:10].O.[OH-].[Na+]>O1CCCC1>[CH3:11][C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([CH3:7])[CH2:9][NH2:10]

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 27975912-Methyl-2-phenylpropanenitrileHCID 21226445Aluminium lithium hydride

生成物 1

HCID 2106022-Methyl-2-phenylpropan-1-amine収率 89.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
80 °C

実験手順

Powdered lithium aluminum hydride (137 mg, 3.61 mmol) was added portionwise to a solution of 2-methyl-2-phenylpropanenitrile (436 mg, 3.00 mmol) in tetrahydrofuran (20 mL). The resulting mixture was stirred at 80° C. overnight. The reaction was then cooled to 0° C. and water (66 μL, 3.7 mmol), 10% sodium hydroxide (1.44 g, 3.6 mmol) and water (195 μL, 10.8 mmol), respectively, were added dropwise into the reaction mixture. The suspension was filtered through anhydrous magnesium sulfate and the solution was concentrated under vacuum to give 2-methyl-2-phenylpropan-1-amine (400 mg) as a yellow oil, which was used for the next step without further purification.

後処理

  1. temperatureThe reaction was then cooled to 0° C.
  2. filtrationThe suspension was filtered through anhydrous magnesium sulfate
  3. concentrationthe solution was concentrated under vacuum

出典と根拠

ORDレコード
ord-6f2c8001aeef46d98bbcb58c5971a5af
出典データセット
uspto-grants-2015_06
特許番号
US09056852B2

反応ノート

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