N-bromobutanimide → HCID 71143824、化合物

HRID 2173044

反応式

HRID 2173044 の反応式
[C:1]1(=[O:9])[C:8]2[N:4]([CH:5]=[CH:6][CH:7]=2)[CH2:3][CH2:2]1.[Br:10]N1C(=O)CCC1=O>C1COCC1>[Br:10][C:6]1[CH:7]=[C:8]2[N:4]([CH2:3][CH2:2][C:1]2=[O:9])[CH:5]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 973473H-1,2-dihydro-1-pyrrolizinone

生成物 1

HCID 71143824HCID 71143824、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
-10 °C

実験手順

A mixture of 2,3-dihydro-1H-pyrrolizin-1-one (300 mg, 2.48 mmol) in THF (20 mL) was cooled to −10° C. in a brine bath. N-Bromosuccinimide (441 mg, 2.48 mmol) in THF (5 mL) was added dropwise, and the reaction mixture was stirred at −10° C. for 1 hour. The reaction was subsequently quenched with water (100 mL) and extracted with ethyl acetate (2×100 mL). The organic layers were combined and dried and to give the title compound, which was used without further purification (520 mg). 1H NMR (400 MHz, DMSO-d6) δ ppm 3.02-3.05 (m, 2H), 4.17-4.20 (m, 2H), 6.58 (d, J=4.40 Hz, 1H), 6.67 (d, J=3.90 Hz, 1H). ESI-MS m/z [M+H]+ calc'd for C7H6BrNO, 200. found, 200.

後処理

  1. customThe reaction was subsequently quenched with water (100 mL)
  2. extractionextracted with ethyl acetate (2×100 mL)
  3. customdried

出典と根拠

ORDレコード
ord-ab0abc6fa410481c9b17703f985a9404
出典データセット
uspto-grants-2015_06
特許番号
US09056873B2

関連ノート

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