Hydrogen Bromide → 2-Amino-5-bromo-1H-pyrrole-3,4-dicarbonitrile

HRID 2175723ノート

反応式

HRID 2175723 の反応式
[C:1]([C:3]([C:9]#[N:10])=[C:4]([C:7]#[N:8])[C:5]#[N:6])#[N:2].[BrH:11]>CC(C)=O.C(OCC)(=O)C.C(O)(=O)C>[NH2:2][C:1]1[NH:6][C:5]([Br:11])=[C:4]([C:7]#[N:8])[C:3]=1[C:9]#[N:10]

参加物

6

反応物 2

HCID 260Hydrogen BromideHCID 12635Tetracyanoethylene

生成物 1

HCID 6109782-Amino-5-bromo-1H-pyrrole-3,4-dicarbonitrile収率 66.8%

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 180Acetone溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Tetracyanoethylene (10.02 g, 78.23 mmol) was dissolved in the mixed solvent of acetone (60 mL) and ethyl acetate (120 mL), to which hydrogen bromide (33 wt %, 60 mL) dissolved in acetic acid was added at 0˜5° C. The yellow solid compound observed after one hour-stirring was isolated by filtering. After washing the compound with cold distilled water (100 mL), the mixture was dried in the air to give the target compound (11.02 g, 52.22 mmol, 66.8%).

後処理

  1. additionwas added at 0˜5° C
  2. customwas isolated
  3. filtrationby filtering
  4. washAfter washing the compound
  5. distillationwith cold distilled water (100 mL)
  6. customthe mixture was dried in the air

出典と根拠

ORDレコード
ord-d6d498be3d55433a8bde26539f9937fe
出典データセット
uspto-grants-2015_06
特許番号
US09062088B2

反応ノート

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