3-Methoxyacetophenone → (+-)-1-(3-Methoxyphenyl)ethanol

HRID 2176987

反応式

HRID 2176987 の反応式
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH3:11])[CH:5]=1)=[O:3].[BH4-].[Na+].[Cl-].[NH4+]>CO>[CH3:11][O:10][C:6]1[CH:5]=[C:4]([CH:2]([OH:3])[CH3:1])[CH:9]=[CH:8][CH:7]=1

参加物

5

反応物 3

HCID 114603-MethoxyacetophenoneHCID 25517Ammonium ChlorideHCID 4311764Sodium borohydride

生成物 1

HCID 90902(+-)-1-(3-Methoxyphenyl)ethanol収率 86.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 3-methoxyacetophenone (3 g; 20 mmol) in methanol (60 mL) is added sodium borohydride (1.13 g; 30 mmol) in four portions over one hour. The reaction is stirred at room temperature overnight, neutralized with saturated ammonium chloride, and extracted with ethyl acetate. The organics are separated, washed with water, and dried over magnesium sulfate. The solvent is removed to give 2.62 grams of 1-(3-methoxyphenyl)-ethanol.

後処理

  1. extractionextracted with ethyl acetate
  2. customThe organics are separated
  3. washwashed with water
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent is removed

出典と根拠

ORDレコード
ord-f34503721ede4d6d87a5b746acb3f354
出典データセット
uspto-grants-2015_06
特許番号
US09067897B2

関連ノート

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