Acetic Acid → 2-(4-Chlorophenyl)-2-oxoethyl acetate

HRID 2177057

反応式

HRID 2177057 の反応式
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1Br)=[O:3].[C:12]([OH:15])(=[O:14])[CH3:13].C(N(CC)CC)C>C(#N)C>[Cl:10][C:7]1[CH:8]=[CH:9][C:4]([C:2](=[O:3])[CH2:1][O:15][C:12](=[O:14])[CH3:13])=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 8471TriethylamineHCID 47126441-(2-Bromo-4-chlorophenyl)ethanone

生成物 1

HCID 5872542-(4-Chlorophenyl)-2-oxoethyl acetate収率 90.1%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
4 °C

実験手順

To a cooled (4° C.) and stirred solution of 2-bromo-4-chloroacetophenone (5.0 g, 21.41 mmol) and glacial acetic acid (2.8 mL, 49.25 mmol) in acetonitrile was added triethylamine (6.1 mL, 44.97 mmol). The reaction mixture was warmed to room temperature, than refluxed for 3 hours. The reaction mixture was extracted with ether, acetate, washed with 1N hydrochloric acid, brine, dried, and concentrated to yield 4.1 g of acetic acid 2-(4-chlorophenyl)-2-oxo-ethyl ester.

後処理

  1. temperatureThe reaction mixture was warmed to room temperature
  2. temperaturethan refluxed for 3 hours
  3. extractionThe reaction mixture was extracted with ether, acetate
  4. washwashed with 1N hydrochloric acid, brine
  5. customdried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-254c1c65fedf4bc7b980642b38967d0e
出典データセット
uspto-grants-2015_06
特許番号
US09067897B2

関連ノート

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