Sodium Hydroxide → HCID 60003036、化合物

HRID 2180525ノート

反応式

HRID 2180525 の反応式
[C:1]([C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:29][CH3:30])=[C:12](/[C:15](/[CH3:28])=[C:16](/[F:27])\[CH:17]=[CH:18]\[C:19](\[CH3:26])=[CH:20]\[C:21]([O:23]CC)=[O:22])[CH:13]=2)[O:8][C:7]([CH3:32])([CH3:31])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>C(O)C.C1COCC1>[C:1]([C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:29][CH3:30])=[C:12](/[C:15](/[CH3:28])=[C:16](/[F:27])\[CH:17]=[CH:18]\[C:19](\[CH3:26])=[CH:20]\[C:21]([OH:23])=[O:22])[CH:13]=2)[O:8][C:7]([CH3:32])([CH3:31])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 22490858HCID 22490858、化合物2 回

生成物 1

HCID 60003036HCID 60003036、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

Following General Procedure G, a solution of ethyl 7-(4-tert-butyl-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)-6-fluoro-3-methyl-octa-2E,4E,6E-trienoate (Compound 109, 32 mg, 0.07 mmol) in ethanol and THF was hydrolyzed with 1M NaOH. Purification by flash chromatography (silica gel, 75:25 hexane/ethyl acetate) afforded the title compound as a light yellow solid.

後処理

  1. customPurification by flash chromatography (silica gel, 75:25 hexane/ethyl acetate)

出典と根拠

ORDレコード
ord-ac7d1415daa040f0bbd33f9dd5ab901f
出典データセット
uspto-grants-2005_05
特許番号
US06887896B1

反応ノート

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