Sodium Hydroxide → HCID 145855861、化合物

HRID 2181657ノート

反応式

HRID 2181657 の反応式
Cl.[NH2:2][OH:3].[OH-].[Na+].[CH:6]([C:8]1[O:9][C:10]2[CH:16]=[C:15]([C:17]([O:19][CH3:20])=[O:18])[CH:14]=[CH:13][C:11]=2[CH:12]=1)=O>CCO>[OH:3]/[N:2]=[CH:6]\[C:8]1[O:9][C:10]2[CH:16]=[C:15]([C:17]([O:19][CH3:20])=[O:18])[CH:14]=[CH:13][C:11]=2[CH:12]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 22481722588702-95-8

生成物 1

HCID 145855861HCID 145855861、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Hydroxylamine hydrochloride (153 mg, 2.2 mmol) is free based for 5 min in 2N NaOH (1.1 ml, 2.2 mmol) and added drop-wise to a solution of methyl 2-formyl-1-benzofuran-6-carboxylate (408 mg, 2.0 mmol) in EtOH (6 ml). The reaction is stirred overnight and the volatiles are removed in vacuo. The residue is suspended in water (5 ml) and the slurry is filtered. The cake is dried overnight to afford 399 mg (91%) of E/Z-methyl 2-[(hydroxyimino)methyl]-1-benzofuran-6-carboxylate as a light brown solid. HRMS (FAB) calcd for C11H9NO4+H: 220.0610, found 220.0602 (M+H)+.

後処理

  1. customthe volatiles are removed in vacuo
  2. filtrationthe slurry is filtered
  3. customThe cake is dried overnight

出典と根拠

ORDレコード
ord-6f7dfc75ebb940b59f710f21d86c1b19
出典データセット
uspto-grants-2005_05
特許番号
US06894042B2

反応ノート

読み込み中…