Hydrochloric Acid → 2,4-dibromo-3-(N,N-di-n-propylaminocarbonylmethoxy)benzoic acid

HRID 2181716ノート

反応式

HRID 2181716 の反応式
[Br:1][C:2]1[C:12]([O:13][CH2:14][C:15]([N:17]([CH2:21][CH2:22][CH3:23])[CH2:18][CH2:19][CH3:20])=[O:16])=[C:11]([Br:24])[CH:10]=[CH:9][C:3]=1[C:4]([O:6]CC)=[O:5].[OH-].[Na+].Cl>C1COCC1.O>[Br:1][C:2]1[C:12]([O:13][CH2:14][C:15]([N:17]([CH2:21][CH2:22][CH3:23])[CH2:18][CH2:19][CH3:20])=[O:16])=[C:11]([Br:24])[CH:10]=[CH:9][C:3]=1[C:4]([OH:6])=[O:5]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12115355ethyl 2,4-dibromo-3-(N,N-di-n-propylaminocarbonylmethoxy)benzoate

生成物 1

HCID 121153562,4-dibromo-3-(N,N-di-n-propylaminocarbonylmethoxy)benzoic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

1.24 g (2.70 mmol) of ethyl 2,4-dibromo-3-(N,N-di-n-propylaminocarbonylmethoxy)benzoate were dissolved in 10 ml of THF and 10 ml of H2O, and 0.117 g of NaOH was added. After stirring at RT for 12 h the mixture was admixed with 6 N HCl and extracted with CH2Cl2. Drying of the organic phase over Na2SO4 gave 2,4-dibromo-3-(N,N-di-n-propylaminocarbonylmethoxy)benzoic acid as a viscous colorless oil.

後処理

  1. extractionextracted with CH2Cl2
  2. dry with materialDrying of the organic phase over Na2SO4

出典と根拠

ORDレコード
ord-fc4edf7db12b47669d183b91be5199c0
出典データセット
uspto-grants-2005_05
特許番号
US06894070B2

反応ノート

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