Trifluoroacetic acid → 4-Carbamoyl-1,2,3,6-tetrahydropyridine trifluoroacetate
反応式
C(OC([N:8]1[CH2:13][CH:12]=[C:11]([C:14](=[O:16])[NH2:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>C(Cl)(Cl)Cl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[C:14]([C:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=1)(=[O:16])[NH2:15]参加物
4
実験手順
In 20 ml of chloroform, 3.7 g of 1-tert-butoxycarbonyl-4-carbamoyl-1,2,3,6-tetrahydropyridine was dissolved, and 13 ml of trifluoroacetic acid were added thereto. The reaction mixture was stirred for 1 hour at room temperature, and subsequently was concentrated under reduced pressure to yield 4.1 g of crude 4-carbamoyl-1,2,3,6-tetrahydropyridine trifluoroacetate as a crystal.
後処理
- concentrationsubsequently was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-bd0780fbc93845618b6d61e206a105ac
- 出典データセット
- uspto-grants-2005_05
- 特許番号
- US06894168B2
反応ノート
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