Sodium Hydroxide → 2-(4-Bromophenyl)-2-methylpropanoic acid

HRID 218222ノート

反応式

HRID 218222 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:15])([CH3:14])[C:9]([O:11]CC)=[O:10])=[CH:4][CH:3]=1.[OH-].[Na+]>O1CCCC1.CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([CH3:15])([CH3:14])[C:9]([OH:11])=[O:10])=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 11277257Ethyl 2-(4-bromophenyl)-2-methylpropanoate

生成物 1

HCID 109336792-(4-Bromophenyl)-2-methylpropanoic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of the product of Example 22A (3.7 g, 13.6 mmoles) in tetrahydrofuran (110.0 ml) and methanol (37.0 ml) was added 2 N sodium hydroxide (19.0 ml) and the solution was stirred at ambient temperature for about 16 hours. The reaction mixture was concentrated in vacuum down to the water layer, was cooled with an ice bath, and was acidified by addition of 2N hydrochloric acid. The precipitate was filtered off and was dried in vacuum to provide the title compound.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuum down to the water layer
  2. temperaturewas cooled with an ice bath
  3. additionwas acidified by addition of 2N hydrochloric acid
  4. filtrationThe precipitate was filtered off
  5. customwas dried in vacuum

出典と根拠

ORDレコード
ord-e4fab534b8164ed0aefc0af450add9b5
出典データセット
uspto-grants-2012_06
特許番号
US08198331B2

反応ノート

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