Simazine → Butylamine

HRID 218278

反応式

HRID 218278 の反応式
[CH:1]([N:4]([CH:7]([CH3:9])[CH3:8])[CH2:5][CH3:6])(C)C.[CH2:10]([NH:12][C:13]1[N:18]=[C:17]([NH:19][CH2:20][CH3:21])[N:16]=C(Cl)[N:14]=1)C.[CH3:23][C:24](N(C)C)=O>>[CH2:10]([NH2:12])[CH2:9][CH2:7][CH3:8].[CH2:7]([N:4]([CH2:5][CH3:6])[C:1]1[N:14]=[C:13]([NH2:12])[N:18]=[C:17]([NH:19][CH2:20][CH2:21][CH2:23][CH3:24])[N:16]=1)[CH3:9]

参加物

5

反応物 3

HCID 5216SimazineHCID 31374Dimethylacetamide2 回HCID 81531Diisopropylethylamine

生成物 2

HCID 8007ButylamineHCID 53746588HCID 53746588、化合物

反応条件

温度
0 °C

実験手順

A solution of 150 millimoles of n-butylamine in 50 ml of dimethylacetamide was prepared and cooled to 0° C. To this solution was added at 0° C. a solution of 250 millimoles of diisopropylethylamine and 50 millimoles of N,N′-diethyl-6-chloro-[1,3,5]triazine-2,4-diamine in 50 ml of dimethylacetamide, the resulting solution was heated under reflux for 4 hours, then cooled to room temperature, and the solvent was distilled off by an evaporator. The reaction mixture was then isolated and purified by silica gel column chromatography to give N,N-diethyl-N″-n-butyl-[1,3,5]triazine-2,4,6-triamine as an oily substance.

後処理

  1. temperaturethe resulting solution was heated
  2. temperatureunder reflux for 4 hours
  3. temperaturecooled to room temperature
  4. distillationthe solvent was distilled off by an evaporator
  5. customThe reaction mixture was then isolated
  6. custompurified by silica gel column chromatography

出典と根拠

ORDレコード
ord-2ce7375c1a764b80a4f996380fadf7b8
出典データセット
uspto-grants-2012_06
特許番号
US08198387B2

関連ノート

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