Ethanolamine → HCID 24012324、化合物

HRID 218279ノート

反応式

HRID 218279 の反応式
[CH2:1]([NH:5][C:6]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:9]=[C:8](Cl)[N:7]=1)[CH2:2][CH2:3][CH3:4].C(N(C(C)C)CC)(C)C.[CH2:27]([CH2:29][NH2:30])[OH:28]>CC(N(C)C)=O>[CH2:1]([NH:5][C:6]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:9]=[C:8]([NH:30][CH2:29][CH2:27][OH:28])[N:7]=1)[CH2:2][CH2:3][CH3:4]

参加物

5

反応物 3

HCID 700EthanolamineHCID 81531DiisopropylethylamineHCID 14045984N~2~,N~4~-Dibutyl-6-chloro-1,3,5-triazine-2,4-diamine

生成物 1

HCID 24012324HCID 24012324、化合物

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

In a 500-ml eggplant-shaped flask were placed 77.8 millimoles of N,N′-dibutyl-6-chloro-[1,3,5]triazine-2,4-diamine, 100 ml of dimethylacetamide, 233.5 millimoles of diisopropylethylamine, and 155.6 millimoles of ethanolamine and the mixture was heated at 160° C. with stirring. After 1.5 hours, the mixture was cooled to room temperature and the solvent was distilled off. A white precipitate in the residue was filtered and the filtrate was purified by silica gel column chromatography to give N,N′-dibutyl-N″-hydroxyethyl-[1,3,5]triazine-2,4,6-triamine.

後処理

  1. customIn a 500-ml eggplant-shaped flask were placed
  2. distillationthe solvent was distilled off
  3. filtrationA white precipitate in the residue was filtered
  4. customthe filtrate was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-12fdd154564e4bf480d4f2c430987dab
出典データセット
uspto-grants-2012_06
特許番号
US08198387B2

反応ノート

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