3-Cyclohexylimidazo[1,5-a]pyrazine → 3-cyclohexyl-5H,6H,7H,8H-imidazo[1,5-a]pyrazine

HRID 2183702

反応式

HRID 2183702 の反応式
[CH:1]1([C:7]2[N:11]3[CH:12]=[CH:13][N:14]=[CH:15][C:10]3=[CH:9][N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>C(O)C.O=[Pt]=O>[CH:1]1([C:7]2[N:11]3[CH2:12][CH2:13][NH:14][CH2:15][C:10]3=[CH:9][N:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

参加物

5

反応物 2

HCID 219836653-Cyclohexylimidazo[1,5-a]pyrazineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 219836083-cyclohexyl-5H,6H,7H,8H-imidazo[1,5-a]pyrazine収率 87.5%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

A solution of 3-cyclohexyl-imidazo[1,5-a]pyrazine 8a (960 mg, 4.4 mmol) in 25 ml ethanol was treated with 100 mg Adam's catalyst and stirred vigorously under one atmosphere of hydrogen for 18 hr. The mixture was filtered through a pad of Celite®. The filtrate was concentrated in vacuo to yield 790 mg of 3-cyclohexyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine 9a as a greenish-yellow solid.

後処理

  1. filtrationThe mixture was filtered through a pad of Celite®
  2. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-b160e3c02ae6415d9a8fb16a78205e97
出典データセット
uspto-grants-2005_05
特許番号
US06900220B2

関連ノート

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