Sodium Hydroxide → 1H-Pyrazolo[4,3-b]pyridine-5-methanol
反応式
[NH:1]1[C:9]2[C:4](=[N:5][C:6]([C:10](OC)=[O:11])=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH-].[Na+]>C1COCC1.CCOCC>[NH:1]1[C:9]2[C:4](=[N:5][C:6]([CH2:10][OH:11])=[CH:7][CH:8]=2)[CH:3]=[N:2]1参加物
6
反応条件
- 温度
- 0 °C
実験手順
1H-pyrazolo[4,3-b]pyridine-5-carboxylic acid, methyl ester (420 mg, 2.37 mmol) was dissolved in THF (30 mL) and cooled to 0° C. LiAlH4 (360 mg, 9.48 mmol) was added in one portion. The mixture was stirred at 0° C. for 3 hr, and diluted with ether. 50% NaOH (5 mL) was added to quench the reaction, and the solid was filtered off through Celite. The filtrate was concentrated, and the residue was purified by flash chromatography to afford 1H-pyrazolo[4,3-b]pyridine-5-methanol (270 mg, 76.4%).
後処理
- customto quench
- customthe reaction
- filtrationthe solid was filtered off through Celite
- concentrationThe filtrate was concentrated
- customthe residue was purified by flash chromatography
出典と根拠
- ORDレコード
- ord-a3d0eb9f03954c208ff630209fd87fa3
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08198456B2
反応ノート
読み込み中…