1-(2-Ethoxy-4-nitrophenyl)piperidin-2-one → HCID 59586675、化合物
反応式
[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[CH:6][C:5]=1[N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][C:14]1=[O:19])[CH3:2].[H][H]>C1COCC1.[Pd]>[NH2:10][C:8]1[CH:7]=[CH:6][C:5]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][C:14]2=[O:19])=[C:4]([O:3][CH2:1][CH3:2])[CH:9]=1参加物
5
実験手順
235 mg (0.889 mmol) of the product from example 90A are dissolved in 40 ml of THF and admixed with 50 mg of 10% palladium on activated carbon. Hydrogenation is effected in a hydrogen atmosphere under standard pressure overnight, then the mixture is filtered with suction through kieselguhr, washed three times with THF and concentrated cautiously under reduced pressure. This affords 262 mg of crude product, which is converted further without purification.
後処理
- filtrationthe mixture is filtered with suction through kieselguhr
- washwashed three times with THF
- concentrationconcentrated cautiously under reduced pressure
- customThis affords 262 mg of crude product, which is converted further without purification
出典と根拠
- ORDレコード
- ord-47053602dd5a418fa447d7183d4fb3fd
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08198267B2
反応ノート
読み込み中…