Triethylamine → N-Methoxy-3-pyridinemethanamine

HRID 2187199ノート

反応式

HRID 2187199 の反応式
Cl.[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8]Cl)[CH:3]=1.Cl.[CH3:11][O:12][NH2:13].C(N(CC)CC)C>C(#N)C>[CH3:11][O:12][NH:13][CH2:8][C:4]1[CH:3]=[N:2][CH:7]=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 233943-(Chloromethyl)pyridine hydrochlorideHCID 521874O-Methylhydroxylamine hydrochloride

生成物 1

HCID 22450426N-Methoxy-3-pyridinemethanamine収率 18.1%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
50 °C

実験手順

In 200 ml of acetonitrile was suspended 6.6 g (0.04 mole) of 3-pyridylmethyl chloride hydrochloride, followed by addition of 10 g (0.12 mole) of O-methyl-hydroxylamine hydrochloride and 16.2 g (0.16 mole) of triethylamine. The mixture was stirred at 50° C. for 15 hours. The insoluble matter was filtered off and the filtrate was concentrated. The residue was subjected to silica gel column chromatography, using EtOH-CHCl3 (1:10) as an eluent. The procedure gave 1.0 g of the title compound as a yellow oil.

後処理

  1. filtrationThe insoluble matter was filtered off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-b2c2391670b34d5c94d1fce0e82f942e
出典データセット
uspto-grants-2002_06
特許番号
US06407248B1

反応ノート

読み込み中…